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Brain imaging also revealed that sucralose altered the functional connectivity between the hypothalamus and other brain regions. For example, after drinking sucralose, participants showed stronger connections between the hypothalamus and areas involved in motivation (like the anterior cingulate cortex) and body awareness (such as the parietal lobule). These changes suggest that sucralose may heighten the brain’s responsiveness to food cues or amplify motivational signals related to eating.

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https://www.psypost.org/a-common-calorie-free-sweetener-alters-brain-activity-and-appetite-control-new-research-suggests/

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